Incidence of Shingles

The incidence of shingles in immunocompromised adults aged ≥18 years exceeds that of immunocompetent adults aged ≥50 years1

Adults who are immunocompromised due to disease or therapy have an increased risk for herpes zoster (HZ).1,2

  • Incidence rates in immunocompromised patients aged ≥18 years ranged between 9 and 96 HZ cases/1000 person-years and were highest in individuals with hematopoietic stem cell transplant, followed by those with hematologic malignancy, solid organ transplant, solid tumor malignancy, and HIV1,*

Herpes Zoster Incidence Rates in Immunocompromised Adults vs Immunocompetent Adults Aged ≥50 Years

Incidence of Herpes Zoster in Immunocompromised Adults Graph
Incidence of Herpes Zoster in Immunocompromised Adults Graph

*Data from a systematic review involving individuals ≥18 years of age with hematopoietic stem cell transplant, hematologic malignancies, solid tumors, HIV, or solid organ transplants.1

The risk of herpes zoster may also be increased in patients with systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, or psoriasis, who may be immunocompromised due to underlying disease or therapy, with incidence rates ranging between 8 and 15/1000 person-years.3

BM=bone marrow transplant; HIV=human immunodeficiency virus; HM=hematologic malignancies; PY=person-years; SCT=stem cell transplant; SOT=solid organ transplant; ST=solid tumors.

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