IF YOU COULD PREVENT SHINGLES, WHY WOULDN’T YOU?

Help protect your patients STARTING AT 50 YEARS OLD FROM SHINGLES

Patient portrayal

Shingles could have more of an impact than you realize

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Protecting patients starts with a strong recommendation from you

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SHINGRIX is $0 for most patients ≥50 years old1,2,*

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  • *

    Coverage and cost may vary and are subject to change without notice. Reimbursement decisions are made by individual insurance plans.

Shingles, a blistering rash that can be excruciatingly painful, is caused by the reactivation of the latent varicella zoster virus.3,4

In 1 out of 3 people,

the dormant virus reactivates in their lifetime and causes shingles3

99.5 percent of people greater than or equal to 50 years old already are infected with the varicella zoster virus

Starting at 50 years old, shingles risk sharply increases3

Incidence rate† of herpes zoster by age–United States3

Zoster virus incidence rate by age in the United States chart

SHINGRIX is a vaccine indicated for prevention of herpes zoster (HZ) (shingles) in adults aged 50 years and older.

Are you vaccinating patients like Jennifer?

JENNIFER, 50 YEARS OLD

  • Mother
  • Business owner
  • Frequent runner
  • No existing medical issues
SEE HOW A SHINGLES EPISODE COULD AFFECT HER
SHINGRIX Patient: Jennifer
Patient portrayal

Proven shingles protection

SHINGRIX delivered greater than 90 percent efficacy against shingles graphic

‡Data from the phase 3 ZOE-50 (≥50 years old) trial (median follow-up period 3.1 years) and pooled data in individuals ≥70 years old from the phase 3 ZOE-50 and ZOE-70 trials (median follow-up period 4 years) in subjects who received 2 doses of SHINGRIX (n=7344 and 8250, respectively) or placebo (n=7415 and 8346, respectively). These populations represented the modified Total Vaccinated Cohort, defined as patients who received 2 doses (0 and 2 months) of either SHINGRIX or placebo and did not develop a confirmed case of herpes zoster within 1 month after the second dose.6,7

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CDC recommendations8,9:

SHINGRIX is recommended for the prevention of herpes zoster and related complications§ for immunocompetent adults ≥50 years old

  • SHINGRIX is recommended regardless of whether they report a prior dose of Zostavax, a shingles vaccine that is no longer available for use in the United States
  • It is not necessary to screen, either verbally or by laboratory serology, for evidence of prior varicella infection


Please visit CDC.gov for full routine shingles vaccination recommendations, including recommendations for immunocompromised adults.

  • §

    SHINGRIX is not indicated for the prevention of herpes zoster-related complications.6

SHINGRIX coadministration with certain other adult vaccines

When your patients’ sleeves are up, don’t miss the opportunity to help protect them from shingles with SHINGRIX

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Start the conversation and recommend SHINGRIX today

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Indication & Important Safety Info

Indication

Important Safety Information

Indication

SHINGRIX is a vaccine indicated for prevention of herpes zoster (HZ) (shingles):

  • in adults aged 50 years and older.
  • in adults aged 18 years and older who are or will be at increased risk of HZ due to immunodeficiency or immunosuppression caused by known disease or therapy.

SHINGRIX is not indicated for prevention of primary varicella infection (chickenpox).

Important Safety Information

  • SHINGRIX is contraindicated in anyone with a history of a severe allergic reaction (eg, anaphylaxis) to any component of the vaccine or after a previous dose of SHINGRIX
  • Review immunization history for possible vaccine sensitivity and previous vaccination-related adverse reactions. Appropriate medical treatment and supervision must be available to manage possible anaphylactic reactions following administration of SHINGRIX
  • In a postmarketing observational study, an increased risk of Guillain-Barré syndrome was observed during the 42 days following vaccination with SHINGRIX
  • Syncope (fainting) can be associated with the administration of injectable vaccines, including SHINGRIX. Procedures should be in place to avoid falling injury and to restore cerebral perfusion following syncope
  • Solicited local adverse reactions reported in individuals aged 50 years and older were pain (78%), redness (38%), and swelling (26%)
  • Solicited general adverse reactions reported in individuals aged 50 years and older were myalgia (45%), fatigue (45%), headache (38%), shivering (27%), fever (21%), and gastrointestinal symptoms (17%)  
  • Solicited local adverse reactions reported in autologous hematopoietic stem cell transplant recipients (aged 18 to 49 and ≥50 years of age) were pain (88% and 83%), redness (30% and 35%), and swelling (21% and 18%)  
  • Solicited general adverse reactions reported in autologous hematopoietic stem cell transplant recipients (aged 18 to 49 and ≥50 years of age) were fatigue (64% and 54%), myalgia (58% and 52%), headache (44% and 30%), gastrointestinal symptoms (21% and 28%), shivering (31% and 25%), and fever (28% and 18%)
  • The data are insufficient to establish if there is vaccine-associated risk with SHINGRIX in pregnant women
  • It is not known whether SHINGRIX is excreted in human milk. Data are not available to assess the effects of SHINGRIX on the breastfed infant or on milk production/excretion
  • Vaccination with SHINGRIX may not result in protection of all vaccine recipients

 

Please see full Prescribing Information.

To report SUSPECTED ADVERSE REACTIONS, contact GSK at https://gsk.public.reportum.com or
1-888-825-5249 or VAERS at 1-800-822-7967 or www.vaers.hhs.gov.

References

  1. Data on file, GSK.

  2. Kirchhoff SM. Selected Health Provisions of the Inflation Reduction Act. Congressional Research Service. 2022; 1-3. Accessed March 1, 2024. https://crsreports.congress.gov/product/pdf/IF/IF12203 

  3. Harpaz R, Ortega-Sanchez IR, Seward JF; Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2008;57(RR-5):1-30.

  4. Shingles symptoms and complications. Centers for Disease Control and Prevention. April 19, 2024. Accessed May 21, 2024. https://www.cdc.gov/shingles/signs-symptoms/index.html

  5. Kilgore PE, Kruszon-Moran D, Seward JF, et al. Varicella in Americans from NHANES III: implications for control through routine immunization. J Med Virol. 2003;70(suppl 1):S111-S118. 

  6. Prescribing Information for SHINGRIX.

  7. Data on file. Study 113077 (NCT01165229). GSK Study Register. Study entry at: https://www.gsk-studyregister.com/en/trial-details/?id=113077

  8. Dooling KL, Guo A, Patel M, et al. Recommendations of the Advisory Committee on Immunization Practices for Use of Herpes Zoster Vaccines. MMWR Morb Mortal Wkly Rep 2018;67:103–108.

  9. SHINGRIX recommendations. Centers for Disease Control and Prevention. Reviewed January 24, 2022. Accessed February 9, 2024. https://www.cdc.gov/shingles/hcp/vaccine-considerations/index.html

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