SHINGLES COULD HAVE MORE OF AN IMPACT THAN YOU REALIZE

Shingles is a painful, itchy rash that develops on one side of the face or body, typically lasting 7 to 10 days.¹

9 out of 10 patients with shingles experienced clinically significant pain

Patients were asked to rate their “worst pain” on a scale of 0 to 10 using the Zoster Brief Pain Inventory. Clinically significant pain was defined as a score of 3 or greater.²

*
Data from a post hoc analysis of two phase 3 trials of participants with a confirmed case of herpes zoster in the placebo group in adults ≥50 years old (n=280) and ≥70 years old (n=240).

How patients describe shingles pain³

Burning

Stabbing

Electric Shocks

Shingles may lead to serious complications^3,†

Postherpetic neuralgia (PHN)³

PHN affects 10% to 18% of patients with shingles. This nerve pain lasts for more than 90 days after the shingles rash and can persist for years.

Herpes zoster ophthalmicus (HZO)³

HZO affects 10% to 25% of patients with shingles. This can lead to ocular complications and, in rare cases, vision loss.

^†
SHINGRIX is not indicated for the prevention of PHN or other herpes zoster-related complications.⁴

Your patients ≥50 years old are at risk for shingles, no matter how healthy they may feel^3,5

Jennifer, 50 years old

Mother
Business owner
Frequent runner
No existing medical issues

How could shingles affect her?

A shingles episode could cause her to close her business for a few weeks, which her family relies on for a majority of its income.

Susan, 52 years old

Sole caregiver to her mother
Goes for walks when she can
Takes prescription medicine for her cholesterol

How could shingles affect her?
The pain during a shingles episode may impact the level of care she provides to her mother.

John, 66 years old

Previously worked on his feet all day
Watches his grandchildren
Manages multiple chronic conditions

How could shingles affect him?

The pain during a shingles episode could limit his ability to watch his grandchildren after school.

A STRONG RECOMMENDATION
FOR SHINGRIX STARTS WITH YOU

Learn how to start the conversation

SEE 3-STEP PLAN

Indication & Important Safety Info

Indication

Important Safety Information

Indication

SHINGRIX is a vaccine indicated for prevention of herpes zoster (HZ) (shingles):

in adults aged 50 years and older.
in adults aged 18 years and older who are or will be at increased risk of HZ due to immunodeficiency or immunosuppression caused by known disease or therapy.

SHINGRIX is not indicated for prevention of primary varicella infection (chickenpox).

Important Safety Information

SHINGRIX is contraindicated in anyone with a history of a severe allergic reaction (eg, anaphylaxis) to any component of the vaccine or after a previous dose of SHINGRIX
Review immunization history for possible vaccine sensitivity and previous vaccination-related adverse reactions. Appropriate medical treatment and supervision must be available to manage possible anaphylactic reactions following administration of SHINGRIX
In a postmarketing observational study, an increased risk of Guillain-Barré syndrome was observed during the 42 days following vaccination with SHINGRIX
Syncope (fainting) can be associated with the administration of injectable vaccines, including SHINGRIX. Procedures should be in place to avoid falling injury and to restore cerebral perfusion following syncope
Solicited local adverse reactions reported in individuals aged 50 years and older were pain (78%), redness (38%), and swelling (26%)
Solicited general adverse reactions reported in individuals aged 50 years and older were myalgia (45%), fatigue (45%), headache (38%), shivering (27%), fever (21%), and gastrointestinal symptoms (17%)
Solicited local adverse reactions reported in autologous hematopoietic stem cell transplant recipients (aged 18 to 49 and ≥50 years of age) were pain (88% and 83%), redness (30% and 35%), and swelling (21% and 18%)
Solicited general adverse reactions reported in autologous hematopoietic stem cell transplant recipients (aged 18 to 49 and ≥50 years of age) were fatigue (64% and 54%), myalgia (58% and 52%), headache (44% and 30%), gastrointestinal symptoms (21% and 28%), shivering (31% and 25%), and fever (28% and 18%)
The data are insufficient to establish if there is vaccine-associated risk with SHINGRIX in pregnant women
It is not known whether SHINGRIX is excreted in human milk. Data are not available to assess the effects of SHINGRIX on the breastfed infant or on milk production/excretion
Vaccination with SHINGRIX may not result in protection of all vaccine recipients

Please see full Prescribing Information.

To report SUSPECTED ADVERSE REACTIONS, contact GSK at https://gsk.public.reportum.com or
1-888-825-5249 or VAERS at 1-800-822-7967 or www.vaers.hhs.gov.

References

Shingles symptoms and complications. Centers for Disease Control and Prevention. April 19, 2024. Accessed May 21, 2024. https://www.cdc.gov/shingles/signs-symptoms/index.html
Curran D, Matthews S, Boutry C, Lecrenier N, Cunningham AL, Schmader K. Natural history of herpes zoster in the placebo groups of three randomized phase III clinical trials. Infect Dis Ther. 2022;11(6):2265-2277.
Harpaz R, Ortega-Sanchez IR, Seward JF; Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2008;57(RR-5):1-30.
Prescribing Information for SHINGRIX.
Kilgore PE, Kruszon-Moran D, Seward JF, et al. Varicella in Americans from NHANES III: implications for control through routine immunization. J Med Virol. 2003;70(suppl 1):S111-S118.

SHINGLES COULD HAVE MORE OF AN IMPACT THAN YOU REALIZE

Shingles is a painful, itchy rash that develops on one side of the face or body, typically lasting 7 to 10 days.¹

How patients describe shingles pain³