Reconstitution & Administration

Watch the video and follow the step-by-step instructions to reconstitute and administer SHINGRIX.

SHINGRIX is a suspension for intramuscular administration only.

Please refer to the full Prescribing Information for SHINGRIX for full details.

Reconstitution Step by Step1

Reconstitution Vial 1 of 2

Vial 1 of 2

AS01B Adjuvant Suspension Component

SHINGRIX Reconstitution: Step 1


Cleanse both vial stoppers. Using a sterile needle and sterile syringe, withdraw the entire contents of the vial containing the adjuvant suspension component (liquid) by slightly tilting the vial. Vial 1 of 2.

Reconstitution Vial 2 of 2

Vial 2 of 2

Lyophilized VZV gE Antigen Component

SHINGRIX Reconstitution: Step 2


Slowly transfer entire contents of syringe into the lyophilized gE antigen component vial (powder). Vial 2 of 2.

VZV=varicella zoster virus; gE=glycoprotein E.

SHINGRIX Reconstitution: Step 3


Gently swirl the vial until powder is completely dissolved. Do not shake vigorously. The reconstituted vaccine should be an opalescent, colorless to pale brownish liquid.

Reconstituted vaccine

SHINGRIX Reconstitution: Step 4


After reconstitution, withdraw 0.5 mL from the vial containing the reconstituted vaccine and administer intramuscularly. The preferred site for intramuscular injection is the deltoid region of the upper arm.  


Prior to reconstitution:
Store both the antigen and adjuvant vials between 2° and 8°C (36° and 46°F). Protect vials from light. Do not freeze; discard if frozen.

After reconstitution: Administer immediately or store refrigerated between 2° and 8°C (36° and 46°F). Discard reconstituted vaccine if not used within 6 hours. Do not freeze; discard if frozen.

You may also be interested in:

Learn how to store SHINGRIX and about the importance of proper dosing.

See what CDC says about SHINGRIX.

Get product coding and coverage details for commercial medical benefit and Medicare Part D insurance.

CDC=Centers for Disease Control and Prevention.