Storage & Dosing

What you should know about the storage and dosing of SHINGRIX before vaccinating your patients.

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Store refrigerated. DO NOT FREEZE:

Prior to reconstitution: Store both the antigen and adjuvant vials between 2° and 8°C (36° and 46°F). Protect vials from light. Do not freeze; discard if frozen.1

After reconstitution: Administer immediately or store refrigerated between 2° and 8°C (36° and 46°F). Discard reconstituted vaccine if not used within 6 hours. Do not freeze; discard if frozen.1

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SHINGRIX is supplied as an adjuvant and antigen for reconstitution:

The antigen is to be reconstituted only with the accompanying adjuvant suspension.1

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SHINGRIX is a vaccine for intramuscular injection only.1

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SHINGRIX is administered as a 2-dose series:

The second dose should be administered anytime between 2 and 6 months after the first dose.1

CDC has issued guidance on the SHINGRIX dosing schedule2,3,*

  • Following the first dose of SHINGRIX, the second dose should be given 2-6 months later
  • If more than 6 months have elapsed since the first dose, administer the second dose as soon as possible. You should not restart the vaccine series
  • However:
    • The efficacy of alternative dosing regimens has not been evaluated
    • Data regarding the safety of alternative regimens are limited
    • Individuals might remain at risk for herpes zoster during a longer than recommended interval between doses 1 and 2

*In a phase 3 clinical study designed to help establish the dosing interval for SHINGRIX, all primary endpoints were met for dosing at a 0- and 6-month interval when compared to dosing at a 0- and 2-month interval. However, a co-primary endpoint (noninferiority) of the immune response was missed for dosing at a 0- and 12-month interval. (The upper limit of the 97.5% confidence interval was 1.53, above the predefined limit of <1.5.)4

GSK has not studied the safety or immune response of 3 doses of SHINGRIX in the indicated population (patients ≥50 years of age).1

CDC=Centers for Disease Control and Prevention.

SHINGRIX Prescription

Prescribing SHINGRIX

When referring patients to a pharmacy, e-prescribe SHINGRIX. The pharmacy will notify your office when the patient has received the first dose. See how you can make the most of your EHR system here.

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