Reconstitution & Administration

Watch the video and follow the step-by-step instructions to reconstitute and administer SHINGRIX.

SHINGRIX is a suspension for intramuscular injection only.1

Please refer to the full Prescribing Information for SHINGRIX for full details.

Reconstitution Step by Step1

Reconstitution Vial 1 of 2

Vial 1 of 2

AS01B Adjuvant Suspension Component

SHINGRIX Reconstitution: Step 1


Cleanse both vial stoppers. Using a sterile needle and sterile syringe, withdraw the entire contents of the vial containing the adjuvant suspension component (liquid) by slightly tilting the vial. Vial 1 of 2.

Reconstitution Vial 2 of 2

Vial 2 of 2

Lyophilized VZV gE Antigen Component

SHINGRIX Reconstitution: Step 2


Slowly transfer entire contents of syringe into the lyophilized gE antigen component vial (powder). Vial 2 of 2.

VZV=varicella zoster virus; gE=glycoprotein E.

SHINGRIX Reconstitution: Step 3


Gently swirl the vial until powder is completely dissolved. Do not shake vigorously. The reconstituted vaccine should be an opalescent, colorless to pale brownish liquid.

SHINGRIX Reconstitution: Step 4


After reconstitution, withdraw 0.5 mL from the vial containing the reconstituted vaccine and administer intramuscularly. The preferred site for intramuscular injection is the deltoid region of the upper arm.  


Icon: Storage

Before reconstitution:

Refrigerate both vials between 2°C and 8°C (36°F to 46°F). Protect vials from light. Discard if frozen.

After reconstitution:

Administer immediately or store refrigerated between 2°C and 8°C (36°F and 46°F) for up to 6 hours. Do not freeze; discard if frozen. Discard if not used within 6 hours.

You may also be interested in:

Learn how to store and properly dose SHINGRIX.

See what CDC says about SHINGRIX.

Learn about the safety profile of SHINGRIX in immunocompromised patients aged 18 years and older.